Mae ymchwil newydd yn datgelu dirgelwch heneiddio celloedd
Scientists have known for decades that the shortening of chromosome telomeres will cause cell aging, but it can only be assumed that DNA damage on telomeres leads to cell aging, which cannot be verified due to the limitation of tools.
Recently, researchers at the University of Pittsburgh in the United States designed a new tool that can only cause oxidative damage to chromosome telomeres, and proved for the first time that oxidative damage to telomeres can lead to cell aging. Understanding this mechanism will help to fight against aging, such as targeting antioxidants to telomeres to protect them from oxidative damage. The related research results have been published in the journal Nature-Structure and Molecular Biology.
Telomere, the key password of human aging!
Nobel scholars found the key password of human aging, which is telomere.
Telomeres, located at the end of chromosomes, are composed of DNA repeats, forming the protection mechanism of chromosomes. When we are born, the telomeres of chromosomes are very long, but as we get older, the chromosomes keep copying, and the telomeres will start to wear out and shorten, and the cells will also age like protective covers at both ends of shoelaces, and the longer we use them, the more they will wear out.
When telomeres become too short, cells can't continue to function normally and begin to decompose. Finally, they will destroy themselves because they lose their protection, and finally die. Scientists call this phenomenon apoptosis.
Scientists have found that the older you get, the shorter the telomeres in cells. The shorter the telomeres, the easier it is to make mistakes in chromosome replication, so there are more diseases. When telomeres disappear completely, cells die.
Anti-oxidation and aging of hydrogen!
Hydrogen molecule has been proved to be a safe and effective antioxidant for cells and genes, which can act on cells, tissues and the whole body. It was found that hydrogen had antioxidant effect, activated anti-aging protein sirt1, promoted AKT phosphorylation, increased glucose uptake in cells, and obviously activated telomerase.
Clinical test: Telomere length increased after drinking hydrogen-rich water for 6 months.
The author of this study is Sergej M. Ostojic, a famous scholar of hydrogen medicine in Serbia. In this randomized controlled pilot clinical trial, the effects of drinking hydrogen-rich water for 6 months on several molecular and phenotypic biomarkers of aging in people aged 70 and above were investigated.
During the 6-month intervention period, 40 elderly people (20 women and 20 men) were randomly assigned to a parallel group design to receive 0.5 L hydrogen water (15 ppm, but 8ppm in their registration information) or a control group drink (0 ppm hydrogen) every day. Biomarkers evaluated at baseline and 6-month follow-up are molecular markers in blood: including DNA and chromosome, nutritional sensation, protein and lipid metabolism, oxidative stress and mitochondria, cell aging, inflammation, etc., brain metabolism, cognitive function, body function and body composition, resting blood pressure, facial skin characteristics, sleep results and health-related quality of life.
The average age of the subjects was 76.0 5.6 years old, their weight was 78.2±16.1 kg, and their height was 167.5±11.5 cm.
In terms of telomere length, the main effect index of this study, there was a significant interaction between treatment and time (P = 0.049). After HRW intervention, the telomere length increased (from 0.99 0.15 at baseline to 1.02 0.26 at follow-up), while after drinking control water, it decreased (from 0.92 0.27 to 0.79 0.15). According to the comparison between the two groups after 6 months, the hydrogen-water group is longer than the control group by more than 25%.
In addition, some studies have found that hydrogen has the effects of anti-aging related diseases such as Alzheimer's disease, metabolic syndrome and arteriosclerosis, and it can also prolong the life of premature aging animals. The concentration of hydrogen in the breath of long-lived elderly people in Japan is higher than that of ordinary people. All these studies suggest that hydrogen may play a certain role in anti-aging.
Generally speaking, the biological effect of hydrogen is selective anti-oxidation, reducing inflammation and oxidative damage. In theory, it may have anti-aging effect, so we can try hydrogen anti-aging daily. Of course, aging is a slow process that continues to happen, and any means must be through long-term effects to really solve the problem. The same is true for improving the state of hydrogen cells, and it will take many years to have an ideal effect.